Table 2.

Summary of statistics of positions significant in the comparison between the hydropathy index of R4X4 and R5 sequences

Mann–Whitney U test
Rank	HXB2 residue	Positiona	p (U-test)b	p (QFD = .05)c	p (QFD = .1)c	Location
1	L	619	.00023	.00086	.0017	Loop-HR2
2	A	667	.00033	.0017	.0034	MPER
3	S	640	.00064	.0026	.0052	HR2
4	R	841	.0009	.0034	.0068	LLP-1
5	N	636	.0027	.0043	.0086	HR2
6	L	641	.0030	.0052	.0104	HR2
7	I	756	.0040	.0060	.0120	MSD3
8	M	535	.0061	.0069	.0138	Fusion peptide
9	E	662	.0067	.0078	.0156	MPER
10	T	723	.0075	.0086	.0172	Minor ectodomain
11	I	746	.0135	.0095	.0190	Minor ectodomain-MSD3
12	Q	658	.0164	.0103	.0206	HR2
χ2 test
Rank	HXB2 residue	Position	p (X 2)b	p (QFD = .05)c	p (QFD = .10)c
1	A	667	.00002	.00086	.0017	MPER
2	L	602	.00013	.0017	.0034	Loop
3	L	641	.00019	.0026	.0052	HR2
4	L	619	.00022	.0034	.0068	Loop-HR2
5	E	662	.0076	.0043	.0086	MPER
6	V	778	.0080	.0052	.0104	LLP-2

^aResidue number is based on the sequence of HXB2 gp120

^bBold characters indicate positions with significant p values using Q_FD = .05. Normal characters indicate aditional positions with significant p values using Q_FD = .1

^cBenjamini-Hochberg critical p values