Table 4.
Pearson’s correlation coefficients (r) for hydrophaty index in gp41 alignments of R5, X4, and R5X4 sequencesa
| R5 | X4 | R5X4 | |||||
|---|---|---|---|---|---|---|---|
| Position 1 | Position 2 | r | p | r | p | r | p |
| 535 | 619 | −0.18 | 5.7E-06 | −0.38 | 5.5E-04 | −0.31 | 4.3E-03 |
| 535 | 636 | 0.26 | 5.7E-11 | 0.32 | 3.2E-03 | 0.29 | 6.9E-03 |
| 535 | 641 | −0.23 | 8.1E-09 | −0.34 | 1.8E-03 | −0.18 | 5.3E-02 |
| 535 | 662 | 0.15 | 7.7E-05 | 0.36 | 7.9E-04 | 0.11 | 1.8E-01 |
| 535 | 723 | −0.29 | 2.7E-13 | −0.47 | 2.0E-05 | −0.27 | 9.6E-03 |
| 535 | 756 | −0.26 | 8.8E-11 | −0.39 | 2.7E-04 | −0.25 | 1.6E-02 |
| 602 | 619 | −0.20 | 3.3E-07 | −0.16 | 8.3E-02 | −0.14 | 9.4E-02 |
| 602 | 640 | −0.22 | 2.4E-08 | −0.15 | 1.1E-01 | −0.44 | 5.9E-05 |
| 602 | 641 | −0.17 | 7.4E-06 | −0.11 | 1.7E-01 | −0.16 | 8.1E-02 |
| 602 | 662 | 0.20 | 9.6E-07 | 0.20 | 4.5E-02 | 0.22 | 2.1E-02 |
| 602 | 723 | −0.22 | 3.3E-08 | −0.10 | 2.1E-01 | −0.40 | 1.8E-04 |
| 602 | 756 | −0.18 | 4.2E-06 | −0.25 | 1.5E-02 | −0.34 | 1.2E-03 |
| 619 | 636 | −0.28 | 4.3E-12 | −0.38 | 3.6E-04 | −0.28 | 7.6E-03 |
| 619 | 640 | 0.20 | 2.6E-07 | 0.17 | 7.9E-02 | 0.47 | 2.6E-05 |
| 619 | 641 | 0.20 | 2.2E-07 | 0.24 | 2.0E-02 | 0.10 | 1.9E-01 |
| 619 | 658 | 0.16 | 2.9E-05 | 0.21 | 3.6E-02 | 0.16 | 8.2E-02 |
| 619 | 662 | −0.45 | 2.0E-29 | −0.51 | 1.4E-05 | −0.54 | 6.4E-07 |
| 619 | 723 | 0.45 | 6.3E-29 | 0.44 | 1.1E-04 | 0.45 | 3.8E-05 |
| 619 | 756 | 0.41 | 2.2E-24 | 0.39 | 4.5E-04 | 0.45 | 2.1E-05 |
| 619 | 841 | 0.25 | 2.5E-10 | −0.03 | 3.8E-01 | 0.36 | 6.4E-04 |
| 636 | 640 | −0.24 | 4.0E-09 | −0.20 | 3.8E-02 | −0.58 | 2.3E-07 |
| 636 | 641 | −0.35 | 6.7E-18 | −0.19 | 5.1E-02 | −0.30 | 3.6E-03 |
| 636 | 662 | 0.19 | 1.2E-06 | 0.28 | 1.0E-02 | 0.21 | 2.8E-02 |
| 636 | 723 | −0.53 | 1.7E-37 | −0.42 | 2.0E-04 | −0.28 | 7.6E-03 |
| 636 | 756 | −0.48 | 1.4E-35 | −0.31 | 4.0E-03 | −0.23 | 2.3E-02 |
| 640 | 641 | 0.28 | 1.7E-13 | 0.35 | 1.5E-03 | 0.35 | 1.2E-03 |
| 640 | 662 | −0.21 | 4.3E-08 | −0.31 | 3.9E-03 | −0.48 | 1.4E-05 |
| 640 | 723 | 0.35 | 3.3E-18 | 0.35 | 1.1E-03 | 0.39 | 3.5E-04 |
| 640 | 756 | 0.29 | 1.5E-12 | 0.16 | 8.8E-02 | 0.45 | 1.9E-05 |
| 641 | 723 | 0.40 | 1.8E-23 | 0.52 | 7.0E-06 | 0.23 | 2.6E-02 |
| 641 | 756 | 0.36 | 6.4E-19 | 0.20 | 3.9E-02 | 0.16 | 7.3E-02 |
| 658 | 662 | −0.18 | 2.5E-06 | −0.26 | 1.1E-02 | −0.13 | 1.2E-01 |
| 658 | 723 | 0.26 | 3.2E-10 | 0.09 | 2.5E-01 | −0.16 | 7.2E-02 |
| 658 | 756 | 0.21 | 3.4E-07 | 0.08 | 2.4E-01 | 0.16 | 7.2E-02 |
| 662 | 723 | −0.45 | 1.5E-29 | −0.42 | 1.5E-04 | −0.49 | 6.9E-06 |
| 662 | 756 | −0.40 | 4.6E-24 | −0.45 | 6.0E-05 | −0.44 | 2.7E-05 |
| 662 | 841 | −0.36 | 1.5E-19 | −0.12 | 1.3E-01 | −0.23 | 2.2E-02 |
| 723 | 756 | 0.71 | 1.5E-66 | 0.61 | 1.3E-07 | 0.67 | 1.5E-09 |
| 723 | 841 | 0.20 | 3.0E-07 | 0.03 | 4.3E-01 | 0.10 | 2.0E-01 |
| 756 | 841 | 0.24 | 1.5E-09 | 0.07 | 2.8E-01 | 0.19 | 4.9E-02 |
a Only correlations with a p-value less than .0001 for at least one coreceptor group are shown