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. 2016 Feb 16;6:21769. doi: 10.1038/srep21769

Figure 3. Postsynaptic AMPAR density is unchanged in Lgi1−/− mice.

Figure 3

(a) Similar ratios of AMPA to NMDA eEPSCs in CA1 pyramidal cells from P8 Lgi1+/+ (n = 6) and Lgi1−/− mice (n = 7; p > 0.05, t-test), with sample traces above. Scale bars: 20 ms, 50 pA. (b) Top: Representative Western blot and quantification of GluR1 and actin bands showing similar GluR1 protein levels in the hippocampus of P8 Lgi1+/+ (n = 4) and Lgi1−/− mice (n = 5; p > 0.05, t-test). Bottom: Representative Western blot and quantification of GluR2/3 and actin bands showing similar GluR2/3 protein levels in the hippocampus of P8 Lgi1+/+ (n = 3) and Lgi1−/− mice (n = 3; p > 0.05, t-test). (c) Representative immunohistochemical staining for GluR1 (top) and extracellular GluR2 (bottom) subunits in hippocampal sections of Lgi1+/+ (n = 3) and Lgi1−/− (n = 3) mice showing similar expression of the AMPAR subunits at P8. Scale bar: 400 μm.