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. 2016 Feb 16;6:21769. doi: 10.1038/srep21769

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(a) Hippocampal electron micrographs from an Lgi1^+/+ mouse showing the subcellular localization of Lgi1, immunostained with patient CSF, in presynaptic elements (arrow) and thin neurites (arrowhead). Non-reactive synaptic contacts are labeled with asterisks. Scale bars: 200 nm. (b) Coefficient of variation (CV) analysis of AMPAR eEPSC amplitude reveals an increase in CV⁻² in CA1 pyramidal cells from P8 Lgi1^−/− (n = 23) compared to Lgi1^+/+ mice (n = 22; p < 0.05, t-test). (c) Synaptic glutamate levels, revealed by γ-DGG (500 μM) inhibition of eEPSC amplitude, are enhanced in P8 Lgi1^−/− (n = 6) compared to Lgi1^+/+ mice (n = 7; p < 0.05, t-test).