Fig. 4.

Functional modules identified by AllegroMCODE based on molecular complex detection (MCODE) algorithm. a–f Representative modules. Circle dots in the modules correspond to mRNAs/proteins. mRNAs/proteins in each module had similar biological functions: Module A was focused on ribosome biogenesis; module B was focused on pathways in cancer, T cell receptor signaling pathway, cell death and apoptosis; module C and D were focused on pathways in cancer; module E was focused on cell cycle; module F was focused on cell cycle and inflammation. Large sizes with red color stand for high degree connectivity, whereas small sizes with green color represent for low degree connectivity