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. 2016 Feb 16;16:9. doi: 10.1186/s12935-016-0280-y

Fig. 4.

Fig. 4

2-DG reduces tumor growth in KP2 xenograft model. ab NSG mice were subcutaneously injected with 1 × 106 KP2 cells. Once the tumor was measurable, two groups of mice were treated by I.P. injection with 800 mg/ml 2-DG or PBS for 15 consecutive days. Representative images of tumors after treatment with PBS or 2-DG are shown (a). Quantification of tumors weight from tumors (P < 0.01) (b). c Ki67, Cleaved Caspase-3 and LC3II were analyzed by IHC in Paraffin-embedded sections of control or treated tumor tissues. df Quantitative analysis of Ki67 Cleaved–caspase3 and LC3II staining in xenograft tissue (P < 0.01)