Table 3. Summary of filtered somatic variants from MAF files of whole exome (WEX) and whole genome (WGS) data by case.
| Case | Sequencing Strategy* | Exonic | Frame Shift | In Frame | Mis-sense | Non-sense | RNA | Silent | Splice Site | Grand Total | Driver genes identified | Driver Variant Allelic Fraction Cellularity % (Path Cellularity %) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TCRBOA1 † | WEX | — | — | — | 5 | — | — | 5 | — | 10 | KRAS | 5 (10) |
| TCRBOA2 † ,* | WEX | — | — | — | 3 | — | — | 3 | 1 | 7 | CDKN2C | 8 (60) |
| TCRBOA3 † ,* | WEX | — | — | — | 8 | — | — | 2 | — | 10 | KRAS, TP53 | from 9–15 (20) |
| TCRBOA4 ‡ | WEX | — | — | — | 9 | 1 | — | 12 | — | 22 | — | N.D. (20) |
| TCRBOA5 † | WEX | — | — | 1 | 5 | 1 | — | 4 | — | 11 | — | N.D. (5) |
| TCRBOA6 ‡ | WEX | — | 3 | 3 | 27 | 1 | — | 9 | 1 | 44 | MEN1, ATXN1 | 55 (80) |
| TCRBOA7 § | WEX | — | 1 | — | 20 | 3 | — | 11 | 2 | 37 | CREBBP, MLL2, NFE2L3 | >50 (90) |
| TCRBOA6 ‡ | WGS | 2 | 3 | 2 | 23 | 1 | 2 | 8 | — | 41 | MEN1 | 63 (80) |
| TCRBOA7 § | WGS | — | 1 | 5 | 20 | 2 | 2 | 14 | 3 | 47 | CREBBP, NFE2L3 | >50 (90) |
*Whole exome sequencing, WEX. Whole genome sequencing, WGS.
†Pancreatic Infiltrating ductal carcinoma.
‡Pancreatic neuroendocrine tumor.
§Follicular lymphoma.