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. 2015 Jun 26;55(11):1286–1292. doi: 10.1002/jcph.540

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© 2015, The Authors. The Journal of Clinical Pharmacology Published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Mean edoxaban plasma concentration–time curves in study 1. Treatment A, two 30‐mg edoxaban immediate‐release tablets; treatment B, 60 mg edoxaban powder formulation delivered to the distal small bowel; treatment C, 60 mg edoxaban powder formulation delivered to the ascending colon; treatment D, 60 mg edoxaban aqueous suspension delivered to the ascending colon. Error bars represent the standard deviation.