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. 2015 Jul 3;76(2):190–208. doi: 10.1002/dneu.22307

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© 2015 The Authors Developmental Neurobiology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Responsiveness of commissural axons to Wnt5a requires canonical Wnt signaling. Wnt5a triggered axon growth from control‐treated commissural neurons (A,B,I). However, commissural axons taken from embryos treated with miLrp5 (C,D), miLrp6 (E,F), or miβCat (G,H) were not responsive to Wnt5a (I). Commissural neurons were stained for Axonin1 (Contactin2) after 30 h of exposure to Wnt5a. Average axon length in control‐treated (miWnt11) neurons was 168.9 ± 11.8 µm after exposure to Wnt5a compared to 89.0 ± 5.9 µm when exposed to control conditioned medium, p < 0.0001. Scale bar: 50 µm. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]