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. 2015 Sep 23;5(6):86–91. doi: 10.1080/2159256X.2015.1096997

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Figure 1. — Model of SINE repression by SUV39H1. Lysine 9 of histone H3 is trimethylated in the vicinity of SINEs by SUV39H1, thereby attracting HP1. The resultant repressive chromatin structure impedes pol III recruitment to SINEs, while having much less effect on TFIIIC. The SUV39H1 inhibitor chaetocin can alleviate this repression and thereby stimulate transcription of SINEs by pol III. Blue line indicates SINE DNA; black line indicates flanking DNA. Red dots signify trimethylated H3K9. Green dots signify methylated DNA.