Table 2.
Timeline of Outcome Measurements for the 3-day Exposure Protocol.
| Time | Day 1 | Day 2 | Day 3 |
|---|---|---|---|
| 9 am | flow-volume | blood (pre) | blood (20-hr post) |
| PC20† | DlCO/lung volumes | flow-volume | |
| sputum (pre) | flow-volume | PC20† | |
| sputum (20-hr post) | |||
| 11 am – 1 pm | 2-hr exposure†† | ||
| 1:10 pm | blood (10-min post) | ||
| flow-volume | |||
| DlCO/lung volumes | |||
| 3 pm | 30-min exercise test | ||
| flow-volume | |||
| 4 pm | sputum (3-hr post) | ||
| blood (3-hr post) | |||
Abbreviations: PC20, methacholine challenge provocation concentration causing a 20% decrease in forced expiratory 1-sec volume from control; DlCO, lung diffusion capacity for carbon monoxide.
The post exposure time in brackets is the time the test was carried out with reference to the end of the 2-hr exposure.
†
Asthmatics only.
††
Respiratory minute ventilation and frequency measured at start and every 30 minutes thereafter.