Table 7.
A comparison of genome-wide linkage scans for language-related phenotypes in previous and current studies. genomic locations use build hg18
| Region | Linkage results from previous studies | Replication results in current study | ||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Phenotype | Markers | Location | Phenotype | Marker | MaxLOD | |
| 16q (SLI1) SLI Consortium (2002, 2004) |
Phonological memory | D16S516-D16S3061 | ∼16:77681517-83492305 | Phonological memory | rs1079635 | 0.19 |
| 19q (SLI2) SLI Consortium (2002, 2004) |
Phonological memory | D19S420-D19S904 | ∼19:48500600-55468843 | Phonological memory | rs1236093 | 0.67 |
| 13q21 (SLI3) Bartlett et al. (2002) |
Reading impairment with SLI | D13S788-D13S317 | ∼13:50790624-81620315 | Language Composite | rs2274202 | 0.355 |
| 7q (SLI4) Vernes et al. (2008) |
Language impairment, phonological memory | rs851715-rs2710117 | ∼7:147829814-147904680 | Phonological memory | rs4431523 | 0.19 |
| 2q36 (SLI5) Wiszniewski et al. (2013) |
Language delay, white matter abnormalities | TM4SF20 | ∼2:227935118-227952266 | Language Composite | rs1403970 | −0.283 |
| 10q Monaco (2007) |
Phonological memory, expressive and receptive language | 163cM | ∼10:130007627-130634338 | Phonological memory | rs1255135 | 0.964 |
| 12p13.31 Addis et al. (2010) |
Language impairment, comorbid literacy difficulties, auditory processing deficit | D12S99-D12S326 | ∼12:5434815-5435185 | Language Composite | rs1558776 | 0.557 |