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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Pharm Sci. 2016 Jan 6;105(2):406–416. doi: 10.1016/j.xphs.2015.10.018

Table 3.

Encapsulated CO-RMs and CO release properties

Refs Macromolecular carriers CO-RMs Trigger release Release rate
Hubbell43 Micelles CO-RM-3 Thiol containing compounds Thiol concentration dependent.
About 10% CO release after 60 min at 10 mM of cysteine.
Schatzschneider44 SiO2 nanoparticles Photo-CO-RM Light Similar to the parent CO-RMs.
Schiller45 Nanoporous fibrous non-wovens CO-RM-1 Light Wavelength dependent
Bernardes46 Proteins (BSA) CO-RM-3 Proteins In 1mg/ml BSA with 50 eq. CO-RM-3, CO release finished in 4 h.