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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Hypertens. 2016 Feb;34(2):196–203. doi: 10.1097/HJH.0000000000000794

Table 2.

Adjusted hazard ratio (95% confidence interval) by complementary log-log analysis for the association between parathyroid hormone level and incident hypertension over a median of 6 years of follow-up: The ARIC Study (1990–1999)

Quintile
1(ref)		 Quintile 2 Quintile 3 Quintile 4 Quintile 5 Linear
trend
P
Overall (N=7,504)
  PTH Median, pg/mL 24.9 32.0 38.2 45.2 58.1
  PTH Range, pg/mL 3.2 – 28.8 28.9 – 34.9 35.0 – 41.5 41.6 – 50.1 50.2 – 162.6
  No. with incident hypertension 350 344 400 426 476
  Crude IR (95% CI), 1000 person-yr 42.8
(38.6, 47.6)		 42.3
(38.0, 47.0)		 49.5
(44.9, 54.6)		 52.7
(47.9, 57.9)		 60.9
(55.5, 66.6)
  Model 1 1 0.95
(0.82, 1.11)		 1.10
(0.95, 1.27)		 1.17
(1.01, 1.35)		 1.25
(1.08, 1.44)		 <0.001
  Model 2 1 0.92
(0.80, 1.07)		 1.05
(0.91, 1.22)		 1.11
(0.96, 1.28)		 1.11
(0.96, 1.28)		 0.020
Whites (N=6,240)
  No. with incident hypertension 296 285 304 317 285
  Crude IR (95% CI), 1000 person-yr 40.5
(36.1, 45.4)		 39.6
(35.3, 44.5)		 44.1
(39.4, 49.4)		 46.6
(41.7, 52.0)		 48.9
(43.6, 54.9)
  Model 1 1 0.95
(0.81, 1.12)		 1.06
(0.90, 1.25)		 1.12
(0.95, 1.31)		 1.15
(0.98, 1.36)		 0.017
  Model 2 1 0.93
(0.79, 1.09)		 1.03
(0.87, 1.21)		 1.06
(0.90, 1.24)		 1.02
(0.86, 1.21)		 0.36
Blacks (N=1,264)
  No. with incident hypertension 54 59 96 109 191
  Crude IR (95% CI), 1000 person-yr 63.0
(48.3, 82.3)		 62.2
(48.2, 80.3)		 80.7
(66.1, 98.6)		 84.7
(70.2, 102.2)		 95.8
(83.1, 110.4)
  Model 1 1 0.98
(0.67, 1.41)		 1.29
(0.92, 1.80)		 1.38
(1.00, 1.92)		 1.53
(1.12, 2.08)		 <0.001
  Model 2 1 0.91
(0.62, 1.32)		 1.19
(0.85, 1.67)		 1.33
(0.95, 1.86)		 1.38
(1.01, 1.89)		 0.003

CI: confidence interval; IR: incidence rate; PTH: parathyroid hormone

Model 1: Adjusted for age, sex, race-center and season; not adjusted for race-center in analyses stratified by race

Model 2: Adjusted for Model 1 plus educational attainment, physical activity, smoking status, alcohol intake, and body mass index