Table 1. Model Replication Helicase Loading and Activation Components.
Initiator | Helicase | SF
(Polarity) |
Loader | Activator | Accessory | |
---|---|---|---|---|---|---|
Eukaryotes | ||||||
Sce/ Hsa | Orc1-6 | MCM2-7 | SF6 (3’-5’) | Cdt1/Cdc6 | CDK/DDK | GINS/Cdc45 |
Archaea | ||||||
Sso/ Mth | Orc1-2(3) | MCM | SF6 (3’-5’) | Cdt1 | - | GINS/RecJ |
Bacteria | ||||||
Eco/ Bsu | DnaA | DnaB | SF4 (5’-3’) | DnaC (DnaI) | - | Rep |
Mitochondria | ||||||
Hsa | - | Twinkle | SF4 (5’-3’) | - | - | - |
Viral | ||||||
papilloma E1 | - | E1 | SF3 (3’-5’) | - | - | - |
polyoma SV40 | - | Large T-ag | SF3 (3’-5’) | - | - | - |
Bacteriophage | ||||||
T4 | - | gp41 | SF4 (5’-3’) | gp59 | - | - |
T7 | - | gp4 | SF4 (5’-3’) | - | - | - |