Table 1. Model Replication Helicase Loading and Activation Components.
| Initiator | Helicase | SF
(Polarity) |
Loader | Activator | Accessory | |
|---|---|---|---|---|---|---|
| Eukaryotes | ||||||
| Sce/ Hsa | Orc1-6 | MCM2-7 | SF6 (3’-5’) | Cdt1/Cdc6 | CDK/DDK | GINS/Cdc45 |
| Archaea | ||||||
| Sso/ Mth | Orc1-2(3) | MCM | SF6 (3’-5’) | Cdt1 | - | GINS/RecJ |
| Bacteria | ||||||
| Eco/ Bsu | DnaA | DnaB | SF4 (5’-3’) | DnaC (DnaI) | - | Rep |
| Mitochondria | ||||||
| Hsa | - | Twinkle | SF4 (5’-3’) | - | - | - |
| Viral | ||||||
| papilloma E1 | - | E1 | SF3 (3’-5’) | - | - | - |
| polyoma SV40 | - | Large T-ag | SF3 (3’-5’) | - | - | - |
| Bacteriophage | ||||||
| T4 | - | gp41 | SF4 (5’-3’) | gp59 | - | - |
| T7 | - | gp4 | SF4 (5’-3’) | - | - | - |