Skip to main content
. 2016 Feb 10;9:681–697. doi: 10.2147/OTT.S95412

Table 2.

lncRNAs as regulators of cell invasion and metastasis in gastric cancer

GC tissues expression GC cell lines expression Assay methods Signaling events References
HOTAIR↑ 19 of 22 GC cell lines↑ Invasion assay, wound-healing assay HOTAIR↑→E-cadherin↓, N-cadherin↑, Snail↑, ZEB1↑→EMT 36
AGS↑, SGC7901↑, HGC27↑ Invasion assay HOTAIR↑→Snail↑→EMT
HOTAIR↑→MMP3, MMP9↑
35
MGC803↑, BGC823↑, AGS↓, SGC7901↓ Migration assay, invasion assay HOTAIR↑→miR-331-3p→HER2↑ 37
SGC7901↑, BGC823↑, AGS↑ Migration assay, invasion assay, right lower lobe of the liver injections assay HOTAIR↑→PCBP1↓ 67
H19↑ MKN45↑, BGC823↑, NCI-N87↓, SNU1↓, SNU16↓, SGC7901↓, MKN28↓ Migration assay, invasion assay, wound-healing assay, abdominal cavity injections assay H19↑→ISM1↑
H19↑→miR-675↑→CALN1↓
25
SGC7901↑, MKN45↑ Invasion assay H19↑→miR-141↓→ZEB1↑
miR-141↑→H19↓→Igf1r, Igf2↑
27
GAPLINC↑ Invasion assay GAPLINC→miR-221-3p→CD44 45, 46
HULC↑ SGC7901↑, BGC823↑, AGS↑ Migration assay, invasion assay, wound-healing assay HULC↑→E-cadherin↓, vimentin↑→EMT 57
CCAT1↑ Migration assay c-Myc↑→CCAT1↑ 47
AK058003 MKN28↑, SGC7901↑, MKN45↑ Migration assay, invasion assay, tail vein injections assay Hypoxia→AK058003→SNCG 69
MALAT2↑ MKN7↑, SGC7901↑, BGC823↑, AGS↑ Migration assay, wound-healing assay MALAT2↑→E-cadherin↓, vimentin↑→EMT
MALAT2→MEK signaling pathway
85
FRLnc1↑ Migration assay, wound-healing assay, tail vein injections assay FOXM1↑→FRLnc1↑→Twist, TGFb1↑ 70
SPRY4-IT1↑ MGC-803↑, SGC7901↑, BGC823↑, MKN45↑, AGS↑, HGC27↑ Migration assay, invasion assay SPRY4-IT1↑→MMP2↑, MMP9↑ 56
SPRY4-IT1↓ SGC7901↓, BGC823↓, AGS↓, HGC27↓, MKN45↓, MKN28↓ Migration assay, invasion assay, tail vein injections assay SPRY4-IT1↓→E-cadherin↓
vimentin↑→EMT
55
BM742401 Migration assay, invasion assay, tail vein injections assay BM742401↑→MMP9 71
FENDRR↓ MGC803↓, MKN28↓, MKN45↓ Migration assay, invasion assay, wound-healing assay, tail vein injections assay FENDRR↓→FN1↑→MMP2/MMP9↑ 72
MEG3↓ HGC-27↓, MGC-803↓, MKN45↓, SGC7901↓, BGC823↓, AGS↓ Migration assay, invasion assay MEG3→miR-181a→bcl-2 64

Notes: ↑, upregulated; ↓, downregulated; –, unknown.

Abbreviations: miR, micro RNA; EMT, epithelial-to-mesenchymal transition; SNCG, synuclein gamma; ZEB1, zinc finger E-box-binding homeobox 1; Igf1r, insulin-like growth factor receptor 1; Igf2, insulin-like growth factor 2; ISM1, isthmin 1; MEK, extracellular signal-regulated kinase; PCBP1, poly r(C)-binding protein 1; HER2, human epithelial growth factor receptor 2; TGFb1, transforming growth factor β1; MMP, matrix metalloproteinase; FN1, fibronectin 1; bcl-2, B cell lymphoma-2; HOTAIR, HOX antisense intergenic RNA; GHET1, gastric carcinoma high expressed transcript 1; CCAT1, colon cancer-associated transcript 1; MALAT2, metastasis associated lung adenocarcinoma transcript 2; GAPLINC, gastric adenocarcinoma-associated positive cluster of differentiation (CD)44 regulator; HULC, highly upregulated in liver cancer; SPRY4-IT1, sprouty 4 intronic transcript 1; MEG3, maternally expressed gene 3; FOXM1, forkhead box protein M1.