Table S1.

Methodological tool of quality assessment of individual studies included for CASR polymorphisms and cancer risk

Criteria	Quality score
Representativeness of cases
Consecutive/randomly selected from case population with clearly defined sampling frame	2
Consecutive/randomly selected from case population without clearly defined sampling frame or with extensive inclusion/exclusion criteria	1
No method of selection described	0
Representativeness of controls
Controls were consecutive/randomly drawn from the same sampling frame (ward/community) as cases	2
Controls were consecutive/randomly drawn from a different sampling frame as cases	1
Not described	0
Ascertainment of cancer diagnosis
Clearly described objective criteria for diagnosis of asthma	2
Diagnosis of asthma by patient self-report or by patient history	1
Not described	0
Ascertainment of controls
Controls were tested to screen out cancer	2
Controls were subjects who did not report cancer; no objective testing	1
Not described	0
Genotyping examination
Genotyping done under “blinded” condition	1
Unblinded or not mentioned	0
Hardy–Weinberg equilibrium
Hardy–Weinberg equilibrium in control group	2
Hardy–Weinberg disequilibrium in control group	1
No checking for Hardy–Weinberg equilibrium	0
Association assessment
Assess association between genotypes and cancers with appropriate statistics and adjustment for confounders	2
Assess association between genotypes and cancers with appropriate statistics without adjustment for confounders	1
Inappropriate statistics used	0