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. 2016 Feb 11;9:57–66. doi: 10.2147/JPR.S97109

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© 2016 Palit et al. This work is published and licensed by Dove Medical Press Limited

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NFR magnitude across CPM phase and the menstrual cycle.

Notes: (A) The PMDD group exhibited CPM of NFR, as indicated by lower NFR magnitudes during ischemia, relative to baseline. CPM of NFR was not observed in HC. (B) Women with PMDD demonstrated greater NFR magnitudes during ovulation, compared to the mid-follicular and late-luteal phases. *Indicates a significant difference (P<0.05).

Abbreviations: PMDD, premenstrual dysphoric disorder; HC, healthy controls; NFR, nociceptive flexion reflex; CPM, conditioned pain modulation; FOL, mid-follicular phase; OVU, ovulatory phase; LUT, late-luteal phase.