Table 1. Differentially regulated lipids between aged and young oocytes.
Upregulated lipids in aged oocytes (6) | Downregulated lipids in aged oocytes (26) | ||||||||
---|---|---|---|---|---|---|---|---|---|
Assignment | Precursor Ion | Product Ion | p-value | Ratio* | Assignment | Precursor Ion | Product Ion | p-value | Ratio* |
TG(56:7) | 922.79 | 577.5 | 0.004 | 2.162 | PI(36:0)** | 881.6 | 607.3 | 0.043 | 0.213 |
PE(36:4) | 740.4 | 599.3 | 0.007 | 1.607 | LPE(18:2) | 478.3 | 337.2 | 0.000 | 0.242 |
hE(20:4) | 690.6 | 369.2 | 0.009 | 1.588 | PI(32:0)** | 825.6 | 551.3 | 0.000 | 0.272 |
PC(36:4) | 782.5 | 183.9 | 0.018 | 1.851 | PI(34:0)** | 853.6 | 579.3 | 0.033 | 0.291 |
PC(36:5) | 780.5 | 183.9 | 0.024 | 1.959 | PI(34:1)** | 851.6 | 577.3 | 0.000 | 0.324 |
PC(38:5) | 808.5 | 183.9 | 0.046 | 1.548 | PI(36:2)** | 877.6 | 603.3 | 0.033 | 0.327 |
PI(34:2)** | 849.6 | 575.3 | 0.008 | 0.350 | |||||
TG(60:3) | 986.82 | 603.5 | 0.048 | 0.354 | |||||
PA(28:5)** | 611.5 | 485.3 | 0.004 | 0.425 | |||||
LPS(18:0)** | 554.3 | 341.2 | 0.029 | 0.444 | |||||
PA(30:1)** | 647.5 | 521.3 | 0.017 | 0.479 | |||||
DG(34:0) | 614.5 | 579.5 | 0.026 | 0.494 | |||||
PA(28:4)** | 613.5 | 487.3 | 0.002 | 0.511 | |||||
dCer1P(d14:1–20:5)** | 638.5 | 210.1 | 0.001 | 0.511 | |||||
PA(30:3)** | 643.5 | 517.3 | 0.030 | 0.524 | |||||
PA(30:0)** | 649.5 | 523.3 | 0.001 | 0.531 | |||||
PA(32:3)** | 671.5 | 545.3 | 0.000 | 0.541 | |||||
DG(32:0) | 586.5 | 551.5 | 0.020 | 0.568 | |||||
SO(d14:1) | 244.3 | 208.1 | 0.003 | 0.577 | |||||
PE(36:3) | 742.4 | 601.3 | 0.008 | 0.579 | |||||
LPC(18:2) | 520.1 | 183.9 | 0.022 | 0.581 | |||||
PS(28:0)** | 708.6 | 495.3 | 0.005 | 0.588 | |||||
LPS(22:6)** | 598.3 | 385.2 | 0.009 | 0.595 | |||||
LPS(18:1)** | 552.3 | 339.2 | 0.016 | 0.632 | |||||
PS(36:1)** | 818.6 | 605.3 | 0.022 | 0.638 | |||||
Cer1P(d18:1–16:1)** | 644.5 | 264.1 | 0.004 | 0.654 |
* Ratio, aged oocytes/young oocytes
** Acidic lipids analyzed after TMSD derivatization.