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. Author manuscript; available in PMC: 2016 Feb 16.
Published in final edited form as: Chem Res Toxicol. 2015 Feb 16;28(2):268–278. doi: 10.1021/tx500505y

Table 1. Formation of 1-Acenaphthenol and 1.2-Epoxyacenaphthene from Oxidation of Acenaphthene and Acenaphthylene, respectively, by Human P450 Enzymes.


P450		 oxidation of acenaphthene oxidation of acenaphthylene
formation of 1-acenaphthenol
(nmol/min/nmol P450)		 formation of 1,2-epoxyacenaphthene
(nmol/min/nmol P450)
P450 2A13 4.5 ± 0.6 0.18 ± 0.03
P450 2A6 6.7 ± 0.8 4.4 ± 0.3
P450 1B1 3.6 ± 0.4 5.3 ± 0.6
P450 1A2 1.5 ± 0.2 2.4 ± 0.3
P450 2C9 0.81 ± 0.33 0.16 ± 0.03
P450 3A4 0.39 ± 0.07 3.8 ± 0.4

Formation of 1-acenaphthenol from acenaphthene and formation of 1,2-epoxyacenaphthene from acenaphthylene by human P450 enzymes were determined with HPLC using a wavelength of 254 nm. Data are means ± SD (range) of duplicate determinations.