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. 2015 Nov 9;4:e09743. doi: 10.7554/eLife.09743

Figure 12. Reduced frequency of miniature excitatory postsynaptic currents (EPSCs) (mEPSCs) in Aplp2-KO and App/Aplp2-dKO CA1 pyramidal neurons.

Figure 12.

(A) Cumulative probability of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated mEPSC inter-event intervals. (B) Cumulative probability of AMPAR-mediated mEPSC amplitudes. Insets in cumulative probability graphs represent average mEPSC frequency (A) and amplitudes (B). mEPSC frequency was significantly reduced in Aplp2-KO and App/Aplp2-dKO CA1 pyramidal neurons as compared to wild-type (WT) but not App-KO littermates. (C) Average mEPSC of the four groups were not significantly different. (D) Cumulative probability of AMPAR-mediated mEPSC decay time with insets representing average mEPSC decay time. mEPSC decay time was significantly increased in App/Aplp2-dKO CA1 pyramidal neurons as compared to WT, App-KO, and Aplp2-KO littermates. (E) Representative recording traces of miniature EPSCs are shown. The number of recordings and the number of mice analyzed for each group are shown in (A). All data represent means ± SEM. Statistical assessment was performed using ordinary one-way ANOVA followed by uncorrected Fisher’s least significant difference (LSD) multiple comparisons test (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).

DOI: http://dx.doi.org/10.7554/eLife.09743.035

Figure 12—source data 1. Source data for statistical analysis of mEPSCs frequency in Figure 12A.
DOI: http://dx.doi.org/10.7554/eLife.09743.036
elife-09743-fig12-data1.xlsx (37.9KB, xlsx)
DOI: 10.7554/eLife.09743.036
Figure 12—source data 2. Source data for statistical analysis of mEPSCs decay time in Figure 12B.
DOI: http://dx.doi.org/10.7554/eLife.09743.037
elife-09743-fig12-data2.xlsx (41.2KB, xlsx)
DOI: 10.7554/eLife.09743.037