Figure 2. Pen1-JCasp is delivered intra-neuronally.
Models of assembly of the amyloid precursor protein (APP) presynaptic interactome and mechanism of action of Pen1-JCasp. (A) SV = synaptic vesicles; AZ = active zone. SV proteins and proteins associated to SV and to the AZ bind via direct and indirect interactions with the JCasp region of APP molecules localized to either SV or the AZ. The interactions depicted here are hypothetical. (B) Pen1-JCasp is delivered intracellularly and can interfere with the interaction of APP with presynaptic proteins. (C) Immune-fluorescence experiment showing that Pen1 delivers the JCasp peptide in hippocampal neurons.