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. 2015 Nov 9;4:e09743. doi: 10.7554/eLife.09743

Figure 4. Pen1-JCasp reduces frequency of excitatory miniature currents.

Figure 4.

(A) Cumulative probability of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) mediated miniature excitatory postsynaptic current (EPSC) (mEPSC) inter-event intervals. (B) Cumulative probability of AMPAR-mediated mEPSC amplitudes. Insets in cumulative probability graphs represent average mEPSC frequency (A) and amplitudes (B). mEPSC frequency was significantly reduced by Pen1-JCasp. (C) Average mEPSC of the two groups were not significantly different. (D) Representative recording traces of miniature EPSCs are shown. The number of recordings and the number of mice analyzed for each group are shown in (A). All data represent means ± SEM. Statistical assessments were performed by paired t test (**p < 0.01).

DOI: http://dx.doi.org/10.7554/eLife.09743.013

Figure 4—source data 1. Source data for statistical analysis of mEPSCs frequency in Figure 4A.
DOI: http://dx.doi.org/10.7554/eLife.09743.014
elife-09743-fig4-data1.xlsx (9.6KB, xlsx)
DOI: 10.7554/eLife.09743.014