Figure 5. Pen1-JCasp reduces the rate of depletion of glutamatergic vesicles.

(A) Artificial cerebrospinal fluid (ACSF) vs Pen1-JCasp, p < 0.05; Pen1-SCJCasp vs. Pen1-JCasp, p < 0.01; (B) ACSF vs. Pen1-JCasp, p< 0.01; Pen1-SCJCasp vs. Pen1-JCasp, p < 0.01. Recovery kinetics (C and D) are not affected. The experiments were performed in 3-month-old C57Bl/6j (A and C) and C57Bl/6j-129 hybrid mice (B and D). All experiments shown in this paper were performed in C57Bl/6j mice, except for the experiments shown in Figure 7; App-KO and wild-type (WT) littermate animals were on a C57Bl/6j-129 hybrid genetic background. Data represent means ± SEM. Statistical assessments were performed by nonlinear regression curve fit, one phase decay.

DOI: http://dx.doi.org/10.7554/eLife.09743.015