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. 2015 Nov 9;4:e09743. doi: 10.7554/eLife.09743

Figure 7. Pen1-JCasp impairs excitatory synapses via an intracellular mechanism.

Figure 7.

Pen1-JCasp, but not JCasp, reduces basal synaptic transmission (A) paired-pulse facilitation (PPF) (B) and frequency facilitation (FF) at 20 Hz (C). Representative traces are shown. Stimulus artifacts are removed from the FF traces for clarity. The number of recordings and of mice analyzed are shown in (B). Statistical assessments were performed by: one-way analysis of variance (ANOVA) followed by Tukey’s multiple comparisons test for slopes of input/output (I/O) curves; two-way repeated measures (RM) ANOVA followed by Tukey’s multiple comparisons test for PPF and FF. *Pen1-JCasp 1 μM vs. artificial cerebrospinal fluid (ACSF), *Pen1-JCasp 1 μM vs. JCasp; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. The complete statistical analyses are shown in the attached Excel file. All data represent means ± SEM.

DOI: http://dx.doi.org/10.7554/eLife.09743.019

Figure 7—source data 1. Source data for statistical analysis of input/output curves in Figure 7A.
DOI: http://dx.doi.org/10.7554/eLife.09743.020
elife-09743-fig7-data1.xlsx (11.9KB, xlsx)
DOI: 10.7554/eLife.09743.020
Figure 7—source data 2. Source data for statistical analysis of paired-pulse facilitation in Figure 7B.
DOI: http://dx.doi.org/10.7554/eLife.09743.021
elife-09743-fig7-data2.xlsx (3.6MB, xlsx)
DOI: 10.7554/eLife.09743.021
Figure 7—source data 3. Source data for statistical analysis of frequency facilitation at 20 Hz in Figure 7C.
DOI: http://dx.doi.org/10.7554/eLife.09743.022
elife-09743-fig7-data3.xlsx (3.6MB, xlsx)
DOI: 10.7554/eLife.09743.022