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. 2015 Nov 9;4:e09743. doi: 10.7554/eLife.09743

Figure 8. Pen1-JCasp reduces the frequency of miniature excitatory postsynaptic currents (EPSCs) (mEPSCs) independently of alterations of Ca+2 influx.

Figure 8.

(A) Cumulative probability of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) mediated mEPSC inter-event intervals. (B) Cumulative probability of AMPAR-mediated mEPSC amplitudes. Insets in cumulative probability graphs represent average mEPSC frequency (A) and amplitudes (B). mEPSC frequency was significantly reduced by Pen1-JCasp in the presence of Cd+2. (C) Average mEPSC of the two groups were not significantly different. (D) Representative recording traces of miniature EPSCs are shown. The number of recordings and the number of mice analyzed for each group are shown in (A). All data represent means ± SEM. Statistical assessments were performed by paired t test (*p < 0.05).

DOI: http://dx.doi.org/10.7554/eLife.09743.023

Figure 8—source data 1. Source data for statistical analysis of mEPSCs frequency in Figure 8A.
DOI: http://dx.doi.org/10.7554/eLife.09743.024
elife-09743-fig8-data1.xlsx (9.4KB, xlsx)
DOI: 10.7554/eLife.09743.024