Table 2.
Likelihood (OR, 95% CI) of moderate or severe prevalent radiographic vertebral fracture (SQ grade ≥ 2) by sex hormone level
| Q1 | Q2 | Q3 | Q4 | Per SD increase | ||
|---|---|---|---|---|---|---|
| SHBG | < 35.7 nmol/liter | ≥35.7–<46.5 nmol/liter | ≥46.5–<59.3 nmol/liter | ≥59.3 nmol/liter | p trend | SD=19.78 |
| N with outcome | 31 (8.5) in 363 | 30 (8.1) in 370 | 35 (9.6) in 365 | 44 (12.1) in 365 | ||
| Age, clinical center adjusted | 0.74 (0.45, 1.22) | 0.67 (0.41, 1.10) | 0.78 (0.48, 1.25) | 1.0 (ref) | 0.174 | 1.19 (1.01, 1.40) |
| Multivariate Adjusted | 0.66 (0.39, 1.13) | 0.57 (0.34, 0.96) | 0.71 (0.44, 1.15) | 1.0 (ref) | 0.079 | 1.24 (1.04, 1.47) |
| Multivariate Adjusted + BMD | 0.70 (0.41, 1.20) | 0.61 (0.36, 1.04) | 0.75 (0.46, 1.23) | 1.0 (ref) | 0.128 | 1.20 (1.01, 1.43) |
| E2 | < 17.2 pg/ml | ≥17.2–<21.7 pg/ml | ≥21.7–<26.9 g/ml | ≥26.9 pg/ml | SD=7.86 | |
| N with outcome | 46 (12.8) in 359 | 30 (8.2) in 368 | 37 (10.1) in 368 | 27 (7.3) in 368 | ||
| Minimally Adjusted | 1.84 (1.11, 3.04) | 1.13 (0.65, 1.95) | 1.42 (0.84, 2.38) | 1.0 (ref) | 0.040 | 0.82 (0.68, 0.98) |
| Multivariate Adjusted | 1.78 (1.07, 2.96) | 1.10 (0.63, 1.93) | 1.39 (0.82, 2.36) | 1.0 (ref) | 0.058 | 0.82 (0.68, 0.99) |
| Multivariate Adjusted + BMD | 1.56 (0.93, 2.62) | 1.05 (0.60, 1.84) | 1.31 (0.76, 2.23) | 1.0 (ref) | 0.162 | 0.86 (0.71, 1.04) |
| T | < 298.0 ng/dl | ≥298.0–<388.0 ng/dl | ≥388.0–<488.0 ng/dl | ≥488.0 ng/dl | SD=161.31 | |
| N with outcome | 39 (10.7) in 366 | 22 (6.0) in 366 | 40 (11.0) in 365 | 39 (10.7) in 366 | ||
| Minimally Adjusted | 0.98 (0.61, 1.57) | 0.52 (0.30, 0.91) | 1.01 (0.63, 1.62) | 1.0 (ref) | 0.424 | 0.96 (0.80, 1.15) |
| Multivariate Adjusted | 0.95 (0.57, 1.58) | 0.53 (0.30, 0.92) | 0.97 (0.60, 1.58) | 1.0 (ref) | 0.394 | 0.96 (0.79, 1.17) |
| Multivariate Adjusted + BMD | 0.95 (0.57, 1.60) | 0.54 (0.31, 0.95) | 0.98 (0.60, 1.59) | 1.0 (ref) | 0.426 | 0.95 (0.78, 1.15) |
| BioE | < 11.3 pg/ml | ≥11.3–<14.0 pg/ml | ≥14.0–<17.0 pg/ml | ≥17.0 pg/ml | SD=4.80 | |
| N with outcome | 50 (13.7) in 365 | 29 (7.9) in 366 | 33 (9.0) in 366 | 28 (7.7) in 366 | ||
| Minimally Adjusted | 1.83 (1.12, 2.99) | 1.00 (0.58, 1.72) | 1.17 (0.69, 1.99) | 1.0 (ref) | 0.024 | 0.77 (0.64, 0.93) |
| Multivariate Adjusted | 1.80 (1.09, 2.97) | 0.96 (0.55, 1.68) | 1.13 (0.66, 1.94) | 1.0 (ref) | 0.031 | 0.77 (0.63, 0.93) |
| Multivariate Adjusted + BMD | 1.47 (0.88, 2.46) | 0.82 (0.47, 1.45) | 1.00 (0.58, 1.73) | 1.0 (ref) | 0.162 | 0.82 (0.67, 0.99) |
| BioT | < 165.4 ng/dl | ≥165.4–<201.5 ng/dl | ≥201.5–<241.9 ng/dl | ≥241.9 ng/dl | SD=64.89 | |
| N with outcome | 37 (10.1) in 367 | 35 (9.6) in 365 | 39 (10.6) in 367 | 29 (8.0) in 364 | ||
| Minimally Adjusted | 1.18 (0.70, 1.98) | 1.16 (0.69, 1.95) | 1.28 (0.77, 2.13) | 1.0 (ref) | 0.682 | 0.85 (0.71, 1.01) |
| Multivariate Adjusted | 1.20 (0.69, 2.10) | 1.18 (0.69, 2.01) | 1.29 (0.77, 2.17) | 1.0 (ref) | 0.633 | 0.82 (0.67, 1.00) |
| Multivariate Adjusted + BMD | 1.16 (0.66, 2.03) | 1.17 (0.68, 2.01) | 1.27 (0.75, 2.15) | 1.0 (ref) | 0.720 | 0.83 (0.68, 1.01) |
Minimally adjusted models include age and clinical center. Multivariate adjusted models include age, clinical center, smoking status, non-white race, height, weight, history of falling, presence of at least one medical condition.