Table 3.
Likelihood (OR, 95% CI) of new or worsening radiographic vertebral fracture (ΔSQ grade ≥ 1) by sex hormone level
| Q1 | Q2 | Q3 | Q4 | Per SD increase | ||
|---|---|---|---|---|---|---|
| SHBG | < 35.7 nmol/liter | ≥35.7–<46.5 nmol/liter | ≥46.5–<59.3 nmol/liter | ≥59.3 nmol/liter | p trend | SD=19.78 |
| N with outcome | 11 (3.9) in 279 | 5 (1.8) in 279 | 18 (7.0) in 259 | 21 (8.9) in 236 | ||
| Minimally Adjusted | 0.54 (0.25, 1.18) | 0.22 (0.08, 0.59) | 0.83 (0.43, 1.63) | 1.0 (ref) | 0.016 | 1.36 (1.07, 1.73) |
| Multivariate Adjusted | 0.54 (0.24, 1.22) | 0.21 (0.08, 0.58) | 0.85 (0.43, 1.68) | 1.0 (ref) | 0.019 | 1.35 (1.05, 1.74) |
| Multivariate Adjusted + BMD | 0.56 (0.24, 1.28) | 0.21 (0.08, 0.60) | 0.86 (0.43, 1.71) | 1.0 (ref) | 0.028 | 1.29 (1.00, 1.67) |
| E2 | < 17.2 pg/ml | ≥17.2–<21.7 pg/ml | ≥21.7–<26.9 pg/ml | ≥26.9 pg/ml | SD=7.83 | |
| N with outcome | 12 (4.8) in 249 | 12 (4.4) in 276 | 17 (6.4) in 266 | 14 (5.3) in 262 | ||
| Minimally Adjusted | 0.99 (0.44, 2.21) | 0.97 (0.43, 2.16) | 1.27 (0.61, 2.66) | 1.0 (ref) | 0.815 | 1.05 (0.81, 1.36) |
| Multivariate Adjusted | 1.00 (0.44, 2.24) | 0.98 (0.44, 2.21) | 1.30 (0.62, 2.75) | 1.0 (ref) | 0.831 | 1.04 (0.81, 1.34) |
| Multivariate Adjusted + BMD | 0.85 (0.37, 1.94) | 0.94 (0.41, 2.13) | 1.26 (0.59, 2.67) | 1.0 (ref) | 0.566 | 1.09 (0.85, 1.41) |
| T | < 298.0 ng/dl | ≥298.0–<388.0 ng/dl | ≥388.0–<488.0 ng/dl | ≥488.0 ng/dl | SD=160.9 | |
| N with outcome | 13 (5.1) in 255 | 14 (5.2) in 269 | 14 (5.4) in 261 | 14 (5.2) in 268 | ||
| Minimally Adjusted | 1.03 (0.47, 2.27) | 1.06 (0.49, 2.29) | 1.03 (0.48, 2.23) | 1.0 (ref) | 0.918 | 1.08 (0.83, 1.40) |
| Multivariate Adjusted | 1.05 (0.46, 2.40) | 1.05 (0.47, 2.32) | 1.03 (0.47, 2.25) | 1.0 (ref) | 0.906 | 1.07 (0.82, 1.41) |
| Multivariate Adjusted + BMD | 1.08 (0.47, 2.48) | 1.07 (0.48, 2.39) | 1.04 (0.47, 2.28) | 1.0 (ref) | 0.854 | 1.06 (0.80, 1.38) |
| BioE | < 11.3 pg/ml | ≥11.3–<14.0 pg/ml | ≥14.0–<17.0 pg/ml | ≥17.0 pg/ml | SD=4.79 | |
| N with outcome | 16 (6.4) in 249 | 9 (3.4) in 264 | 16 (6.0) in 266 | 14 (5.1) in 274 | ||
| Minimally Adjusted | 1.26 (0.59, 2.69) | 0.68 (0.29, 1.62) | 1.23 (0.58, 2.59) | 1.0 (ref) | 0.865 | 0.93 (0.71, 1.21) |
| Multivariate Adjusted | 1.26 (0.59, 2.72) | 0.67 (0.28, 1.62) | 1.30 (0.61, 2.78) | 1.0 (ref) | 0.900 | 0.93 (0.71, 1.22) |
| Multivariate Adjusted + BMD | 1.02 (0.46, 2.23) | 0.57 (0.23, 1.39) | 1.18 (0.55, 2.56) | 1.0 (ref) | 0.666 | 1.00 (0.76, 1.32) |
| BioT | < 165.4 ng/dl | ≥165.4–<201.5 ng/dl | ≥201.5–<241.9 ng/dl | ≥241.9 ng/dl | SD=64.81 | |
| N with outcome | 15 (6.4) in 234 | 14 (5.3) in 264 | 13 (4.8) in 270 | 13 (4.6) in 285 | ||
| Minimally Adjusted | 1.33 (0.60, 2.92) | 1.25 (0.57, 2.75) | 1.05 (0.47, 2.35) | 1.0 (ref) | 0.422 | 0.86 (0.65, 1.14) |
| Multivariate Adjusted | 1.31 (0.57, 3.02) | 1.27 (0.56, 2.85) | 1.07 (0.48, 2.39) | 1.0 (ref) | 0.459 | 0.86 (0.65, 1.15) |
| Multivariate Adjusted + BMD | 1.29 (0.55, 2.99) | 1.27 (0.56, 2.87) | 1.10 (0.49, 2.48) | 1.0 (ref) | 0.512 | 0.88 (0.66, 1.17) |
Minimally adjusted models include age and clinical center. Multivariate adjusted models include age, clinical center, smoking status, non-white race, height, weight, history of falling, presence of at least one medical condition.