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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Bone. 2016 Jan 8;84:271–278. doi: 10.1016/j.bone.2016.01.009

Table 4.

Risk (HR, 95% CI) of clinical vertebral fracture by sex hormone level

Q1 Q2 Q3 Q4 Per SD increase
SHBG < 35.7 nmol/liter ≥35.7–<46.5 nmol/liter ≥46.5–<59.3 nmol/liter ≥59.3 nmol/liter p trend
 N with outcome 8 (2.2) in 363 10 (2.7) in 371 10 (2.7) in 367 17 (4.6) in 368 SD=19.78
 Minimally Adjusted 0.55 (0.23, 1.31) 0.65 (0.29, 1.44) 0.61 (0.28, 1.35) 1.0 (ref) 0.176 1.19 (0.92, 1.53)
 Multivariate Adjusted 0.53 (0.21, 1.31) 0.65 (0.29, 1.45) 0.60 (0.27, 1.32) 1.0 (ref) 0.167 1.19 (0.91, 1.55)
 Multivariate Adjusted + BMD 0.55 (0.22, 1.37) 0.63 (0.28, 1.44) 0.63 (0.29, 1.41) 1.0 (ref) 0.179 1.14 (0.88, 1.48)
E2 < 17.2 pg/ml ≥17.2–<21.7 pg/ml ≥21.7–<26.9 pg/ml ≥26.9 pg/ml SD=7.86
 N with outcome 13 (3.6) in 361 8 (2.2) in 369 13 (3.5) in 368 11 (3.0) in 371
 Minimally Adjusted 1.34 (0.60, 3.01) 0.82 (0.33, 2.05) 1.27 (0.57, 2.85) 1.0 (ref) 0.693 0.89 (0.66, 1.19)
 Multivariate Adjusted 1.40 (0.62, 3.14) 0.86 (0.34, 2.16) 1.36 (0.60, 3.05) 1.0 (ref) 0.631 0.88 (0.66, 1.17)
 Multivariate Adjusted + BMD 1.19 (0.53, 2.71) 0.81 (0.32, 2.06) 1.26 (0.56, 2.86) 1.0 (ref) 0.893 0.92 (0.69, 1.23)
T < 298.0 ng/dl ≥298.0–<388.0 ng/dl ≥388.0–<488.0 ng/dl ≥488.0 ng/dl SD=161.31
 N with outcome 12 (3.3) in 366 11 (3.0) in 368 11 (3.0) in 365 11 (3.0) in 370
 Minimally Adjusted 1.08 (0.47, 2.45) 0.93 (0.40, 2.16) 0.96 (0.42, 2.23) 1.0 (ref) 0.880 1.08 (0.82, 1.43)
 Multivariate Adjusted 1.11 (0.47, 2.64) 0.94 (0.40, 2.23) 0.99 (0.42, 2.31) 1.0 (ref) 0.844 1.08 (0.81, 1.44)
 Multivariate Adjusted + BMD 1.06 (0.44, 2.53) 0.93 (0.39, 2.23) 1.05 (0.45, 2.46) 1.0 (ref) 0.962 1.07 (0.81, 1.41)
BioE < 11.3 pg/ml ≥11.3–<14.0 pg/ml ≥14.0–<17.0 pg/ml ≥17.0 pg/ml SD=4.80
 N with outcome 14 (3.8) in 367 15 (4.1) in 367 7 (1.9) in 367 9 (2.5) in 368
 Minimally Adjusted 1.60 (0.69, 3.71) 1.63 (0.71, 3.72) 0.78 (0.29, 2.09) 1.0 (ref) 0.117 0.80 (0.59, 1.09)
 Multivariate Adjusted 1.69 (0.72, 3.97) 1.69 (0.73, 3.94) 0.84 (0.31, 2.26) 1.0 (ref) 0.102 0.79 (0.59, 1.07)
 Multivariate Adjusted + BMD 1.40 (0.59, 3.36) 1.50 (0.63, 3.58) 0.78 (0.28, 2.13) 1.0 (ref) 0.240 0.85 (0.62, 1.16)
BioT < 165.4 ng/dl ≥165.4–<201.5 ng/dl ≥201.5–<241.9 ng/dl ≥241.9 ng/dl SD=64.89
 N with outcome 14 (3.8) in 367 10 (2.7) in 367 12 (3.3) in 367 9 (2.5) in 368
 Minimally Adjusted 1.40 (0.60, 3.30) 1.12 (0.45, 2.77) 1.22 (0.51, 2.92) 1.0 (ref) 0.494 0.99 (0.73, 1.34)
 Multivariate Adjusted 1.46 (0.60, 3.57) 1.20 (0.48, 3.02) 1.26 (0.52, 3.05) 1.0 (ref) 0.453 0.98 (0.72, 1.34)
 Multivariate Adjusted + BMD 1.28 (0.52, 3.16) 1.18 (0.47, 3.00) 1.24 (0.51, 3.00) 1.0 (ref) 0.640 1.02 (0.75, 1.39)