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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Neuropharmacology. 2015 Dec 22;103:279–289. doi: 10.1016/j.neuropharm.2015.12.016

Fig. 3. DRG neurons have decreased KNa component of IK current upon inhibition of p38 MAPK.

Fig. 3

(a) Top- Representative traces from whole-cell recordings of DRG neurons treated with 10 μM p38 Inhibitor for 90 minutes at 37 °C, in bath solution containing sodium. Bottom, Current-Voltage relationship of IK measured from p38 Inhibitor-treated DRG neurons in bath solution containing sodium. (b) Top- Representative traces from whole-cell recordings of DRG neurons treated with 10 μM p38 Inhibitor for 90 minutes at 37 °C, in bath solution containing the impermeant cation NMG in place of sodium. Bottom, Current-Voltage relationship of the isolated KNa current measured from Inhibitor-treated DRG neurons in bath solution containing NMG. Holding potential was −70 mV, and currents were elicited with voltage steps from −120 mV to +120 mV in 20 mV increments. Data are means ± SEM (n=8–12 per group). Statistical analysis was done using Student’s unpaired t-test (*p<0.05).