Fig. 6. p38 MAPK does not affect gating of the Slack channel.

(a,b) Representative traces of channels recorded from an excised inside-out patch perfused with 20 mM and 90 mM Na⁺ in Slack stable HEK cells, after treatment with Vehicle (0.01% DMSO, A) or p38 Inhibitor (10 μM, B) for 90 minutes at 37°C. (c) Na⁺ dose response relationship of vehicle- and p38 Inhibitor-treated Slack HEK cells. NP (0) values were calculated from 33 sweeps over 2400 ms at each dose of Na⁺. Data are means ± SEM (n=4).