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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Ann Neurol. 2015 Dec 25;79(2):272–287. doi: 10.1002/ana.24559

Figure 5. Phase-specific regional tau neuropathology in PiD.

Figure 5

Photomicrographs depict representative images from CNS areas sequentially involved in our hypothetical model of the progressive spread of tau pathology in PiD (AT-8). Cervical spinal cord (A) showing a moderate amount of tau neuropathology in the intermediolateral and upper Rexed layers of the spinal cord corresponding to Phase II–IV pathology. High power images reveal neuronal tau inclusions (arrows) in the upper Rexed layers (II–III) (B) and intermediolateral layer (VII) and (D) relative sparing on lower motor neurons (arrow) in layers VIII–IX. Tau inclusions in (E) pontine nuclei in the basis pontis with severe tau pathology (arrows) in the LC (F) and RPN (G) characteristic of Phases II–IV. The inferior olivary pre-cerebellar nucleus (H) with dot-like stippling pattern of tau reactivity (arrows; inset =40x magnification) seen in Phases III–V. Finally, a mild degree of tau positive PBs (arrows) and diffuse astrocytic tau inclusions (asterisks) in the primary visual cortex (I) representing end-stage Phase IV pathology.