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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Ann Neurol. 2015 Dec 25;79(2):272–287. doi: 10.1002/ana.24559

Figure 7. Spatial and temporal gradient of mature tau pathology in PiD.

Figure 7

Photomicrographs depict panel of markers of mature tau pathology. Case #1 classified as Phase I had (A) an absence of ThS staining and minimal (B) Tau C3 and (C) UBQ reactivity in the dentate gyrus (arrows). In contrast, case #15 classified as Phase IV had (D) mild to moderate ThS stained PBs in the dentate gyrus of the hippocampus, (G) rare to mild reactivity in OFC (arrows) and (J) rare or no reactivity in SENS. The C-terminal truncation epitope labeled by Tau C3 MAb revealed most consistent tau reactivity in the dentate gyrus (E) and superficial neocortical layer (II–III) pick bodies (arrows) and ramified astrocytes (asterisks) in OFC (H) with mild amounts in SENS (arrow) (K). UBQ-reactive PBs showed consistent staining in DG (F), with less prominent reactivity in OFC (arrows) (I) and SENS (arrow) (L).