Table 4.

Extraction of intact and manipulated sotalol test formulation 1 in 100 mL of water and different solvent at room temperature. (n=3)

Type of sample	Solvent Level	Solvent	Extraction (%)
			5 min	15 min	30 min	60 min
Intact dosage form	Level 0	H2O	5.0 ± 0.4	4.4 ± 0.5	14.4 ± 0.4	23.8 ± 3.1
	Level 1	5% EtOH	8.9 ± 0.9	7.8 ± 0.2	11.8 ± 1.2	18.7 ± 0.4
		40% EtOH	2.2 ± 0.4	5.5 ± 0.4	7.6 ± 1.4	12.2 ± 1.9
		0.1 M Acetic Acid	5.0 ± 1.6	9.6 ± 0.9	15.1 ± 0.8	23.7 ± 1.2
		0.1 M NaHCO3	4.0 ± 0.9	7.5 ± 0.4	13.0 ± 0.4	19.0 ± 0.3
		0.9% NaCl	2.9 ± 0.2	6.3 ± 1.1	9.9 ± 1.9	16.2 ± 1.8
	Level 2	70% IPA	0.8 ± 0.1	1.9 ± 0.1	3.3 ± 0.5	6.0 ± 0.9
		100% IPA	0.1 ± 0.0	0.2 ± 0.0	0.6 ± 0.1	1.0 ± 0.1
		0.1 N HCl	3.4 ± 0.2	7.8 ± 0.9	11.1 ± 0.4	18.0 ± 1.4
		0.1 N NaOH	3.5 ± 0.4	7.8 ± 0.2	12.9 ± 1.8	18.9 ± 1.2
		Acetone	0.6 ± 0.1	1.3 ± 0.2	2.2 ± 0.3	3.5 ± 0.5
Manipulated dosage form	Level 0	H2O	45.1 ± 15.8	54.3 ± 6.9	68.2 ± 5.6	76.5 ± 4.7
	Level 1	5% EtOH	38.0 ± 2.6	52.7 ± 2.3	63.2 ± 1.8	75.2 ± 2.3
		40% EtOH	27.5 ± 1.4	49.5 ± 3.0	63.7 ± 2.8	73.8 ± 1.6
		0.1 M Acetic Acid	34.2 ± 3.4	55.5 ± 2.8	67.1 ± 3.2	75.4 ± 3.3
		0.1 M NaHCO3	22.5 ± 1.8	40.0 ± 1.1	57.1 ± 2.1	68.7 ± 0.8
		0.9% NaCl	19.9 ± 1.8	41.8 ± 2.6	55.1 ± 3.3	69.0 ± 2.3
	Level 2	70% IPA	22.7 ± 1.3	49.1 ± 10.4	63.6 ± 3.5	75.6 ± 5.4
		100% IPA	19.1 ± 1.8	39.0 ± 2.1	58.0 ± 1.3	69.9 ± 3.1
		0.1 N HCl	37.5 ± 4.8	44.5 ± 4.4	51.4 ± 5.3	55.5 ± 4.5
		0.1 N NaOH	21.5 ± 2.2	42.5 ± 3.0	64.4 ± 4.9	86.3 ± 7.4
		Acetone	45.1 ± 15.8	54.3 ± 6.9	68.2 ± 5.6	76.5 ± 4.7