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Improvements of GM and WM segmentation in a subject where the cortex is significantly more folded than the age-specific average template. Top row: manual segmentation; Middle row: atlas-based automatic segmentation (DSC: GM 0.7580, WM 0.8882); Bottom row: PBAEM (DSC: GM 0.8477 with improvement of 0.0897, WM 0.9151 with improvement of 0.0269). Red arrows: GM-WM boundaries where PBAEM was proved to generate more accurate labeling than atlas-based approach.
