. Author manuscript; available in PMC: 2016 Feb 16.

Published in final edited form as: Biochemistry. 2016 Feb 3;55(6):837–849. doi: 10.1021/acs.biochem.5b00965

Table 4.

Binding affinities of nuclease-resistant analogs measured for the phosphodiesterase protein GdpP^a

Modification	Analog	K_i(µM)	Fold Change
Ribose	c-di-dAMP	200 ± 18	1.5
	c-di-2’F-AMP	26 ± 3.6	0.2
	c-dA-2’F-A	9.4 ± 0.8	0.07
	c-di-2’OMe-AMP	15 ± 2.5	0.12
Phosphate	c-(R_pR_p)-di-A_ps	260 ± 2.7	2.0
	c-(R_pS_p)-di-A_ps	210 ± 17	1.6

Data are the average of at least three independent trials of inhibitor concentration from 50 µM – 5 mM.