Table 4.
Modification | Analog | Ki(µM) | Fold Change |
---|---|---|---|
Ribose | c-di-dAMP | 200 ± 18 | 1.5 |
c-di-2’F-AMP | 26 ± 3.6 | 0.2 | |
c-dA-2’F-A | 9.4 ± 0.8 | 0.07 | |
c-di-2’OMe-AMP | 15 ± 2.5 | 0.12 | |
Phosphate | c-(RpRp)-di-Aps | 260 ± 2.7 | 2.0 |
c-(RpSp)-di-Aps | 210 ± 17 | 1.6 |
Data are the average of at least three independent trials of inhibitor concentration from 50 µM – 5 mM.