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Interconnections between the Hippo and RB/E2F pathways. (A) Common regulation of cell cycle genes by YAP/TAZ-TEAD and activating E2F transcription factors. (B) Negative regulation of cell cycle gene transcription by LATS1/2 through activation of the repressive DREAM complex. (C) Regulation of osteogenic differentiation by TAZ and RB through activation of RUNX2 transcription factors.
