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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Curr Opin Microbiol. 2015 Dec 17;29:68–73. doi: 10.1016/j.mib.2015.11.005

Figure 1.

Figure 1

EHEC responds to microbiota-derived metabolites to activate complex regulatory cascades. EHEC senses ethanolamine, butyrate, and succinate to activate virulence gene expression, whereas the two-component system FusKR represses LEE expression in response to fucose. Ethanolamine is sensed through EutR as well as an unidentified ethanolamine sensor; butyrate is sensed through the transcription factor Lrp; succinate is sensed by Cra. Black lines indicate direct interaction, and grey hashed arrows indicate indirect regulation. For details, refer to main text.