Intraocular pressure (IOP) measurements in normal cats during the pre-treatment (A), treatment (C) and post-treatment (E) phases and in glaucomatous cats during pre-treatment (B), treatment (D) and post-treatment (F) phases. Normal cats demonstrated a significant increase in mean IOP in the treated eye following drug administration, with maximal increase at 4h. Application of latanoprost 0.005% led to a significant reduction in IOP of the treated eye in glaucomatous cats, with maximal IOP reduction at 3h. Statistically significant differences are indicated by *p<0.05 latanoprost-treated eye (OD) vs. vehicle-treated control eye (OS); **p<0.01, treated vs. control; ***p <0.0001, treated vs. control; (Paired t-test); ††p<0.01, post- vs. pre-treatment value; ‡ p<0.001, post- vs. pre-treatment value (Repeated Measures ANOVA).