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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: J Med Chem. 2015 Jul 6;59(4):1440–1454. doi: 10.1021/acs.jmedchem.5b00405

Figure 6.

Figure 6

Cocrystal structure of 8i with TRIM24(PHD-bromo)(1.8 Å resolution) showing the n-propyl ether group occupying the “upper pocket” and the dimethylamino group forming a salt-bridge to D926 in the ZA-channel (PDB 4YC9).