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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: J Med Chem. 2015 Jul 6;59(4):1440–1454. doi: 10.1021/acs.jmedchem.5b00405

Scheme 1. Synthesis of Sulfonamides 5a–e, 6, 7a–f.

Scheme 1

Reagents and conditions: (a) sulfonyl chloride, pyr, DCM; (b) Br2, AcOH, CHCl2, 0 °C; (c) phenol intermediate, CuCl, quinolin-8-ol, potassium phosphate, diglyme, 120-130 °C; (d) TFA2O, DMAP, Et3N, DCM; (e) phenol intermediate, CuI, N,N-dimethyl-glycine, Cs2CO3, dioxane, 80 °C; (f) sulfonyl chloride, pyr, DCM.