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. Author manuscript; available in PMC: 2017 Feb 25.
Published in final edited form as: J Med Chem. 2015 Jul 6;59(4):1440–1454. doi: 10.1021/acs.jmedchem.5b00405

Scheme 3. Synthesis of Derivatives 8a–c.

Scheme 3

Reagents and conditions: (a) 1-bromopropane, K2CO3, DMF; (b) Z(CH2)6-Br, K2CO3, DMF; (c) 10b, CuI, N,N-dimethyl-glycine, Cs2CO3, dioxane, 80 °C; (d) 1-methyl-1H-imidazole-4-sulfonyl chloride, pyr, DCM; (e) TFA, DCM.