. Author manuscript; available in PMC: 2017 Feb 25.

Published in final edited form as: J Med Chem. 2015 Jul 6;59(4):1440–1454. doi: 10.1021/acs.jmedchem.5b00405

Table 1.

Structure-Activity Relationship for Sulfonamides 3a–e and 5a–g

Cmpd	R	X	TRIM-24 IC₅₀ (μM)^a
3a	4-SMe	H	4.8 ± 2.9 (5)
3b	2,4-di-OMe	H	2.5 ± 0.56 (3)
3c	4-O-iso-butyl	H	3.7 ± 3.2 (3)
3d	4-cyclohexyl	H	2.8 ± 1.3 (6)
3e	H	OMe	36 ± 24 (9)
5a	4-SMe	H	4.9 ± 0.82 (5)
5b	4-OMe	H	9.3 ± 5.1 (3)
5c	H	H	23 ± 2.6 (3)
5d	4-O-iso-butyl	H	4.0 ± 1.3 (5)
5e	4-cyclohexyl	H	1.7 ± 0.69 (5)
5f	3-CN	OMe	10 ± 2.7 (6)
5g	H	O(4-MeO-Ph)	1.5 ± 0.79 (11)

Mean ± SEM (number of measurements)