Table 2.
Changes from baseline for A1C, FPG, insulin detemir dose, and body weight in patients aged <65 and ≥65 years
| Parameter | <65 yearsa | ≥65 yearsa | Mean estimated differences in changes from baseline between groupsb | ||||
|---|---|---|---|---|---|---|---|
| n | Mean change | SD (SE) | n | Mean change | SD (SE) | ||
| A1C (%) | 1219 | −0.56 | 1.5 (0.04) | 584 | −0.47 | 1.3 (0.05) | 0.094, p = 0.17 |
| Fasting plasma glucose (mg/dL) | 1221 | −21.8 | 83.7 (2.4) | 582 | −25.5 | 70.2 (2.9) | −3.70, p = 0.33 |
| Insulin detemir dose (U/kg) | 1268 | 0.19 | 0.3 (0.008) | 603 | 0.11 | 0.2 (0.008) | −0.078, p < 0.0001 |
| Body weight (kg) | 1500 | −0.13 | 5.5c (0.14) | 719 | −0.49 | 5.1c (0.19) | −0.356, p = 0.13 |
Data for A1C, FPG, and insulin detemir dose were from the efficacy analysis set; body weight came from the safety set
FPG fasting plasma glucose, SD standard deviation, SE standard error
aData shown are for observed mean changes within each age group
bData shown are for differences between age groups for changes from baseline (Day 1) to the end of Week 26 (≥65 − <65)
cSD values for body weight changes are large because the gap between the minimum and maximum values was wide