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. 2015 Oct 8;55:249–255. doi: 10.1007/s40262-015-0315-x

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Individual changes in trough concentration (C _trough) values for a tamoxifen and b endoxifen following the switch from a potent cytochrome P450 (CYP) 2D6-inhibiting antidepressant (paroxetine [Parox] or fluoxetine [Fluox]) to a weak CYP2D6-inhibiting antidepressant (escitalopram), and mean plasma concentration–time profiles for c tamoxifen and d endoxifen during concomitant use of paroxetine or fluoxetine (white circles) and during concomitant use of escitalopram (black circles)