Table 1.
Altered glycans and glycan-related genes in EMT.
| Glycan type | EMT model | Altered glycan or glycan-related gene |
Reference | |
|---|---|---|---|---|
| Glycan | Gene | |||
| N-glycan | Human hepatocellular carcinoma cell | β1,4-N-acetylglucosaminyltransferase III (GnT-III), β1,4-N-acetylglucosaminyltransferase V (GnT-V), fucosyltransferase 8 (FUT8), and β1-3-galactosyltransferase, polypeptide 5 (β3GalT5) | (14) | |
| Human mammary epithelial cell | Bisecting N-glycans | GnT-III | (15) | |
| Non-tumorigenic mouse hepatocyte cell | GnT-V | (16) | ||
| Human mammary epithelial cell | fucosyltransferase IV (FUT4) | (17) | ||
| Human non-small cell lung cancer | FUT8 | (18) | ||
| Human giant lung carcinoma cell | Core fucosylation | FUT8 | (19) | |
| α2,6-sialylated N-glycan | β-galactoside α2,6-sialyltransferase 1 | (20) | ||
| Human keratinocyte cell | Sialylated N-glycan | (21) | ||
| Mouse mammary epithelial cell | High-mannose-type; antennary N-glycans, fucosylation and bisecting GlcNAc N-glycans | α1,2-mannosyltransferase ALG9, MGAT3 (GnT-III), and β1,4-N-acetylglucosaminyltransferase 4B (MGAT4B or GnT-IVb) | (22) | |
| Human bladder epithelial cell | α2,6-sialyltranferase 1(st6gal1), neuraminidase 1 (Neu1), hexosaminidase B (HexB), mannosidase, class 2A, member 1(MAN2A1), fucosidase, α-l-1(Fucα1) | (23) | ||
| O-glycan | Human breast epithelial cell | polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6) | (30) | |
| Human prostate epithelial cell | GALNT3, GALNT6 | (31) | ||
| Glycosphingolipids (GSLs) | Human and mouse breast epithelial cell | Gg4, GM2 | β1,3-galactosyltransferase-4 (β3GalT4) | (40, 41) |
| Human lens epithelial cell | GM3 | (42) | ||
| Human breast cancer cell | α2,8-sialyltransferase 1 (GD3 synthase) | (43) | ||