Figure 4.

R₁, R₂, and PD values for the spatially normalized brain images of the group of MS patients, plotted in the same manner as Figure 3 for the R₁–R₂ (A) and R₂–PD (B) projections. Additionally, the thick black line indicates the transition from 100% V_FW (the red dot at “FW”) to 100% V_CL (the red dot at “CL”) until 40% V_MY, using the model parameter settings for the healthy controls (Table 1). The grid of gray lines indicates the expected changes in R₁, R₂, and PD values for the pathological brain under myelin loss (Figure 1C) and under the presence of excess parenchymal water (Figure 1D). The cross points of the grid are placed at each 5% change in V_MY and each 10% change in V_EPW. The V_MY partial volume is indicated by the gray numbers 0–40%. The V_EPW partial volume is indicated by the blue numbers 20–80%.