Table 3.
The mean myelin partial volume VMY, cellular partial volume VCL, and the excess parenchymal water partial volume VEPW of various brain structures, estimated as a percentage of the acquisition voxel volume.
| Healthy controls |
Multiple sclerosis patients |
|||||||
|---|---|---|---|---|---|---|---|---|
| VMY (%) | VCL (%) | VEPW (%) | MWF (%) | VMY (%) | VCL (%) | VEPW (%) | MWF (%) | |
| Insula | 8 | 75 | 17 | 4 | 8 | 66 | 26 | 4 |
| Cingulate cortex | 12 | 81 | 7 | 7 | 8 | 78 | 14 | 4 |
| Caudate nucleus | 9 | 87 | 4 | 5 | 6 | 59 | 35 | 3 |
| Cortical gray matter | 15 | 74 | 11 | 9 | 14 | 66 | 20 | 8 |
| Pons | 18 | 69 | 13 | 11 | 17 | 60 | 23 | 10 |
| Putamen | 15 | 85 | 0 | 9 | 15 | 85 | 0 | 9 |
| Mid brain | 19 | 81 | 0 | 12 | 18 | 79 | 3 | 11 |
| Thalamus | 19 | 81 | 0 | 12 | 16 | 84 | 0 | 9 |
| Occipital white matter | 18 | 82 | 0 | 11 | 15 | 83 | 2 | 9 |
| Frontal white matter | 21 | 77 | 2 | 14 | 19 | 73 | 8 | 11 |
| Parietal white matter | 21 | 77 | 2 | 14 | 19 | 73 | 8 | 11 |
| Sub-lobar white matter | 25 | 66 | 9 | 16 | 21 | 65 | 14 | 13 |
| White matter | 23 | 75 | 2 | 15 | 19 | 73 | 8 | 11 |
| Corpus callosum | 27 | 60 | 13 | 18 | 25 | 55 | 20 | 16 |
The values were calculated using the proposed model and the reported relaxation rates R1 and R2 and proton density PD in the WFU Pickatlas ROIs of the spatially normalized, averaged group of healthy controls and the spatially normalized, averaged group of multiple sclerosis patients from Ref. (21) (Table 2, cropped ROI templates). Added are the expected myelin water fraction MWF values, calculated as PDMY/(PDCL + PDEPW).