Table 4.
The mean myelin partial volume VMY, cellular partial volume VCL, and the excess parenchymal water partial volume VEPW of various brain structures, estimated as a percentage of the acquisition voxel volume.
| Healthy controls |
Multiple sclerosis patients |
|||||||
|---|---|---|---|---|---|---|---|---|
| VMY (%) | VCL (%) | VEPW (%) | MWF (%) | VMY (%) | VCL (%) | VEPW (%) | MWF (%) | |
| Cingulate cortex | 2 | 96 | 2 | 1 | 2 | 95 | 3 | 1 |
| Caudate nucleus | 8 | 92 | 0 | 4 | 9 | 91 | 0 | 5 |
| Cortical gray matter | 2 | 95 | 3 | 1 | 2 | 95 | 3 | 1 |
| Putamen | 11 | 89 | 0 | 6 | 10 | 90 | 0 | 5 |
| Thalamus | 19 | 81 | 0 | 12 | 15 | 84 | 1 | 9 |
| Occipital white matter | 34 | 57 | 9 | 25 | 31 | 61 | 8 | 22 |
| Frontal white matter | 36 | 62 | 2 | 28 | 34 | 64 | 2 | 25 |
| Corpus callosum | 41 | 56 | 3 | 35 | 36 | 60 | 4 | 29 |
The values were calculated using the proposed model and the relaxation rates R1 and R2 and proton density PD in manually placed ROIs in all participants of Ref. (21). Added are the expected myelin water fraction MWF values, calculated as PDMY/(PDCL + PDEPW).