Table 1.

Summary of Fmr1 KO phenotypes tested for mimic or rescue by manipulation of mGlu5-Homer scaffolds^a

Fmr1 KO phenotype	Rescued with H1a deletionb	Mimicked in mGlu5R/R
Decreased mGlu5-Homer scaffolds	X	X
Decreased mGlu5 association with postsynaptic density	NT	X
Enhanced, mGlu5-dependent protein synthesis rates and translation initiation complexes	X	X
Enhanced, mGlu5-dependent activation of ERK and mTORC1 signaling pathways	NT	X
Deficient DHPG-induced activation of ERK and mTORC1 signaling	X	X
Enhanced DHPG-induced phosphorylation of EF2	X	X
Prolonged neocortical UP states	X	X
Audiogenic seizures	Partial	Partial
Reduced PPI	NT	X
Increased open field activity	X	X
Increased open arms in T-maze	NT	X
Decreased floating in Porsolt swim test	NT	X
Enhanced protein levels of FMRP target mRNAsc	No	No
Deficient DHPG-induced increase in protein levels of FMRP target mRNAsc	No	X
Enhanced mGluR-LTD magnitudec	No	No
Protein synthesis-independent mGluR-LTDc	No	X

^aNT, Not tested.

^bRonesi et al. (2012).

^cPhenotypes that do not result from abnormal mGlu5-Homer scaffolds but other functions of FMRP.